Understanding proton affinity of tyrosine sidechain in hydrophobic confinement#
نویسندگان
چکیده
منابع مشابه
Evaporation rate of water in hydrophobic confinement.
The drying of hydrophobic cavities is believed to play an important role in biophysical phenomena such as the folding of globular proteins, the opening and closing of ligand-gated ion channels, and ligand binding to hydrophobic pockets. We use forward flux sampling, a molecular simulation technique, to compute the rate of capillary evaporation of water confined between two hydrophobic surfaces ...
متن کاملPathways to dewetting in hydrophobic confinement.
Liquid water can become metastable with respect to its vapor in hydrophobic confinement. The resulting dewetting transitions are often impeded by large kinetic barriers. According to macroscopic theory, such barriers arise from the free energy required to nucleate a critical vapor tube that spans the region between two hydrophobic surfaces--tubes with smaller radii collapse, whereas larger ones...
متن کاملHydrophobic Affinity Chromatography of Proteins
1. Chromatographic studies have been made of the affinities of a number of purified proteins for agarose (Sepharose 4B) substituted with 4-phenylbutylamine (PBA) or with E-aminocaproyl-n-tryptophan methyl ester (ACTME) as compared to controls of untreated agarose and/or of cyanogen bromide treated agarose without addition of a substituting amine. 2. At pH 8, cu-chymotrypsin (3.4.4.5) and 7s y-g...
متن کاملProgress in Understanding Confinement
In recent years a research program was developed to investigate dual superconductivity of the vacuum as a mechanism of confinement of color in QCD. The original idea goes back to t’Hooft and Mandelstam, and is, modulo duality transformation, the same as confinement of magnetic charges in a type 2 superconductor. The end points of an Abrikosov flux tube can be viewed as monopoles; their energy i...
متن کاملUnderstanding Confinement From Deconfinement
We use effective magnetic SU(N) pure gauge theory with cutoff M and fixed gauge coupling gm to calculate non-perturbative magnetic properties of the deconfined phase of SU(N) Yang-Mills theory. We obtain the response to an external closed loop of electric current by reinterpreting and regulating the calculation of the one loop effective potential in Yang-Mills theory. This effective potential g...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Chemical Sciences
سال: 2012
ISSN: 0974-3626,0973-7103
DOI: 10.1007/s12039-011-0196-y